The challenges of bone infection and re-infection
As a doctor, you have experience in the prevention and treatment of bone infections, re-infections and biofilms.
You are familiar with the challenge of
- Biofilm
- Osteomyelitis
- Reconstruction of bony defects
- Reconstruction of bony defects
- Death space management
- PJI
- FRI
- SSI
- Infected pseudarthrosis
- Resistance to antibiotics
Reasons to use OS-Pure and why is
OS +Vanco / +Tobra impregnated with
high-dose antibiotics?
Effective strategies for the prevention of infections such as osteomyelitis are described in the clinical literature. Our procedure guarantees the purest and safest quality of bone grafts. This enables the bone to be impregnated with antibiotics, which are then transplanted with high bioavailability. This method enables a local, high-dose release of antibiotics. OS +Vanco / +Tobra ensures a prolonged release of antibiotics above the MIC level for at least 42 days, thus preventing re-infections and biofilm. When using
OS +Vanco / +Tobra , no white drainage occurs even at high volumes
Importantly, OS +Vanco / +Tobra has no adverse effects on post-operative renal function, even in patients with co-morbidities. (EBJIS 2024, treatment of osteomyelitis using cancellous allograft bone impregnated with antibiotics – Hauer, Moshammer, Leithner – MedUni Graz).
| Properties of the ECTB allografts | Info | OS +Vanco/+Tobra | OS-Pure |
|---|---|---|---|
| Bone Graft Impacting | Yes |
|
|
| White Drainage/White leakage | Never |
|
|
| May have contact with soft tissue | Yes |
|
|
| Highest concentration of antibiotics |
10cc = 1.000mg Vancomycin
10cc = 400mg Tobramycin |
|
|
| Osteokonductiv | Yes |
|
|
| Osteoinductiv | Promoting through intact collagen |
|
|
| Risk of mixing errors or too early/fast curing | Never |
|
|
| Simple and easy mixing and combining, even with autograft | Yes |
|
|
| Remodelling to bone | Yes |
|
|
| Halo effect | No through complete remodelling |
|
|
| Release of vancomycin (Study MedUni Graz/Austria and King's College Hsp. London) |
Day 1: 40mg/mL Day 21: 20mg/mL Day 42: 18mg/mL |
|
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| Hohe primäre Stablilität | Yes Kings College study |
|
|
| Is the product also used without the addition of antibiotics? | Yes |
|
contact us
Do you have any questions or need further information? Write to us or contact us by phone – we’ll be happy to help you!